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It serves as an exclusive substrate for two enzyme families vital for cellular repair and longevity—sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs)

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The ability of the microbiota to affect CNS activities bidirectionally through the vagus nervous system (VNS) is mainly mediated by the neurological (ANS), hormonal (HPA axis), and immunological (cytokine and chemokine) processes, all of which are interrelated (52)